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Pfizer. Diflucan fluconazole tablets, injection for intravenous infusion only, and for oral suspension prescribing information. New York, NY; 2004 Aug. If reactions are severe, discontinue Exjade and institute appropriate medical intervention. INH therapy for 4 months. HbE beta-thalassemia in 49 30% patients, and alpha-thalassemia in 22 13% patients. hemob.info nifedipine

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Dorko, C. Subcutaneous phytonadione for reversal of warfarin-induced elevation of the International Normalized Ratio. Having both radiation and can make this worse. So can or drinking alcohol during the time you are getting radiation therapy. These symptoms usually go away within a month after radiation treatment is completed. Breast cancer. Population research suggests that higher dietary intake of vitamin K2 is linked with a lower risk of developing breast cancer.

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GlaxoSmithKline. Agenerase amprenavir capsules prescribing information. Research Triangle Park, NC; 2002 Oct. DALIRESP if such events occur. The effects of your blood-thinner may decrease and increase your risk for blood clots. If your rifamycin is stopped, there is an increased chance for bleeding.

Percent reduction is defined as 100 1-RR

Kindelan JM, Serrano I, Jurado R, Villanueva JL, Garcialazaro M, Garciaherola A, Cisneros JT "Rifampin-induced severe thrombocytopenia in a patient with pulmonary tuberculosis. Astellas Pharma US. Mycamine micafungin sodium for injection prescribing information. Deerfield, IL; 2006 Jun. Lewis, J. H. Total body phylloquinone and its turnover in human subjects at two levels of vitamin K intake. Product Information. Rifadin rifampin.



How to take rifampicin

Isoniazid-rifampin is contraindicated in patients with previous hepatic injury or severe adverse reactions such as drug fever, chills, and arthritis associated with isoniazid. Isoniazid-rifampin is also contraindicated in patients with history of drug-induced hepatitis. Rifampin especially since I will be on it for at least a month. DALIRESP is not a bronchodilator and is not indicated for the relief of acute bronchospasm. Matsumoto, H. High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature. Nutr. CDC and others recommend these patients receive once-daily or 3-times weekly rifampin regimens. Add 100 mL of syrup to the bottle and shake vigorously. Overdose can cause worsening symptoms such as nausea, vomiting, stomach pain, itching, headache, and lack of energy, leading to loss of consciousness. What should I avoid while taking rifampin? Rifampin can make birth control pills less effective. Ask your doctor about using non hormonal birth control condom, diaphragm with spermicide to prevent pregnancy while taking rifampin. Two medicines, ursodiol UDCA and ocaliva, can be used to treat PBC. Both medicines help move bile out of the liver into the small intestine. And Ocaliva decreases the amount of made by the liver. Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995. To reduce the development of drug-resistant bacteria and maintain the effectiveness of rifampin and other antibacterial drugs, rifampin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Side effects from radiation therapy are a problem. Usually the side effects are temporary. But some side effects may be permanent. Researchers keep looking for the lowest radiation dose that effectively kills cancer cells. And with new technology, people getting radiation therapy have fewer problems than in the past. Gleser, G. Hemorrhagic disease of the newborn. Breast feeding as a necessary factor in the pathogenesis. Cashman, K. D. Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.



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In the randomized, parallel group, double-blind trials, RE-COVER and RE-COVER II, patients with deep vein thrombosis and pulmonary embolism received Pradaxa 150 mg twice daily or warfarin dosed to target INR of 2 to 3 following initial treatment with an approved parenteral anticoagulant for 5-10 days. WBCs. Had knee replacement June 2007 and had to be removed secondary to MRA in sept 2007. After three more surgeries using spacer and IV Vancomycin for 4-5 months, had re-implantation of knee. No problems with flare ups until August 2010. At first flare ups were short and far between. As time went on, flareups became more severe and lasted longer and were more frequent. US Centers for Disease Control and Prevention. National action plan to combat multidrug-resistant tuberculosis. Meeting the challenge of multidrug-resistant tuberculosis: summary of a conference. Management of persons exposed to multidrug-resistant tuberculosis. MMWR Recomm Rep. Blurred vision; burning or discomfort in the eye, including stinging, redness, and itching; dry eyes; eye pain; foreign body sensation; sensitivity to sunlight; tearing. Renal side effects have included elevations in BUN and serum uric acid. Hemoglobinuria, hematuria, interstitial nephritis, acute tubular necrosis, renal insufficiency, and acute renal failure have been reported. These events are generally associated with an immune-mediated reaction which occurs after interruption in rifampin therapy. Standard doses may produce orange-colored urine. By altering the number of tablets according to the patient's body weight, complete treatment is delivered without the need for calculation of dose. Shearer, M. J. Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover. Typically, they consist of flushing and itching with or without a rash. More serious cutaneous reactions which may be due to hypersensitivity occur but are uncommon. This is to be expected while you are taking rifampin, isoniazid, and pyrazinamide. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. Therefore, it is best not to wear soft contact lenses while taking rifampin, isoniazid, and pyrazinamide. Hard contact lenses are not discolored by rifampin, isoniazid, and pyrazinamide. This condition will return to normal once you stop taking rifampin, isoniazid, and pyrazinamide. If you have any questions about this, check with your doctor. Haubenstock A, Schmidt P, Zazgornik J, Balcke P, Kopsa H. Hypoprothrombobinaemic bleeding associated with ceftriaxone. Venco, A. Low dose oral vitamin K to reverse acenocoumarol-induced coagulopathy: a randomized controlled trial. Thromb. diflucan



Before taking rifampicin

Isoniazid use should be carefully monitored in patients with the following: severe renal dysfunction, chronic liver disease, concurrent use of any chronically administered medication, or daily ingestion of alcohol. To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed. The accompanying study is excellent and groundbreaking. The uniform improvement in liver-function tests for patients who started with abnormal liver function matches findings for our patients with hepatitis C who were given statins. This study is the first to show an additional benefit of reducing cardiovascular events in patients with abnormal liver-function tests. No studies show how many patients are denied statins because of pre-existing changes in liver-function tests, or how many patients have statins discontinued when ALT increases. Carefully administering sodium bicarbonate if pyridoxine and diazepam do not control seizure activity. Use caution against overcorrection and watch for hypokalemia or hyperkalemia. Papaioannou, D. Vitamin K to prevent fractures in older women: systematic review and economic evaluation. Health Technol. Rifampin should be used with caution in patients with a history of diabetes mellitus, as diabetes management may be more difficult. Hansten PD. Isoniazid drug interactions. Drug Interactions Newsletter 1983; 32: 7-11. The World Health Organization WHO recommends the fixed-dose combination of rifampin 150 mg, isoniazid 75 mg, pyrazinamide 400 mg, and ethambutol 275 mg for the daily administration in the initial phase of tuberculosis treatment. Berbatis CG, Eckert GM, Woods V "Nephropathy associated with rifampicin. Abadi FJR, Carter PE, Cash P et al. Rifampin resistance in Neisseria meningitidis due to alterations in membrane permeability. Antimicrob Agents Chemother. Patients should be instructed to notify their physicians promptly if they experience any of the following: fever, loss of appetite, malaise, nausea and vomiting, darkened urine, yellowish discoloration of the skin and eyes, and pain or swelling of the joints.



INH daily to complete 6 months of therapy

Deykin, D. Low-Dose Vitamin K Therapy in Excessively Anticoagulated Patients: A Dose-Finding Study. Therefore, take this drug at evenly spaced intervals, or exactly as directed. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection. True RJ. Interactions between antibiotics and oral contraceptives. JAMA 1982; 24710: 1408. High-dose rate brachytherapy HDR brachytherapy: Radioactive material is placed into an organ, such as the prostate, for a very brief period of time seconds to minutes and then removed. Although 2-drug regimens of rifampin and pyrazinamide were previously used for treatment of LTBI, 176 177 194 215 t v these regimens have been associated with an increased risk of hepatotoxicity and are no longer recommended for treatment of LTBI. 257 269 t v See Hepatic Effects under Cautions. Food and Drug Administration. Joos AAB, Frank UG, Kaschka WP. Pharmacokinetic interaction of clozapine and rifampicin in a forensic patient with an atypical mycobacterial infection. J Clin Pharmacol. The American Thoracic Society ATS. Ad Hoc Committee on the Scientific Assembly on Microbology, Tuberculosis, and Pulmonary Infections. Treatment of tuberculosis and tuberculosis infection in adults and children. Infants and children under 30 kg of body weight: Use is not recommended. order injectable gefitinib



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Centers for Disease Control and Prevention. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR Recomm Rep. ATS, CDC, IDSA, and others. Take this medicine with a full glass of water. Take Pradaxa exactly as prescribed by your doctor. Lackner TE. Interaction of dexamethasone with phenytoin. For patients treated with two PIs, the complexity of drug interactions is amplified, and recommendations about dose modifications are difficult when rifamycins also are administered. However, if ritonavir taken in doses ranging from 100 mg to 600 mg twice per day is combined with any other PI for HIV therapy, and the administration of rifabutin also becomes necessary, the need to use substantially reduced doses of rifabutin 150 mg two or three times per week is certain. In comparison, for a patient who is undergoing treatment with saquinavir SGC a relatively weak CYP450 inhibitor and two NRTIs, the usual dosage 300 mg daily or two or three times per week of rifabutin should not be decreased.



Rifampicin consumer information

Patients should be informed that rifampin may cause a brownish-red or orange discoloration of urine, tears, feces, saliva, sputum, and sweat. Permanent discoloration of contact lens may occur. CYP3A inhibitor erythromycin for 4 months. Chronic or rectal irritation. Szulc P, Meunier PJ. Is vitamin K deficiency a risk factor for osteoporosis in Crohn's disease? The patient should be told that rifampin may produce a reddish coloration of the urine, sweat, sputum, and tears, and the patient should be forewarned of this. Soft contact lenses may be permanently stained. Reed JB, Scales DK, Wong MT et al. Bartonella henselae neuroretinitis in cat scratch disease. Diagnosis, management, and sequelae. Ophthalmology. Ethambutol diffuses into actively growing M. tuberculosis such as tubercle bacilli. Ethambutol appears to inhibit the synthesis of one or more metabolites, thus causing impairment of cell metabolism, arrest of multiplication, and cell death. No cross resistance with other available antimicrobial agents has been demonstrated. Therapeutic levels of rifampin have been shown to inhibit standard microbiological assays for serum folate and vitamin B 12. Thus, alternate assay methods should be considered. Treatment of MAC infections is complicated and should be directed by clinicians familiar with mycobacterial diseases; consultation with a specialist is particularly important when the patient cannot tolerate first-line drugs or when the infection has not responded to prior therapy or is caused by macrolide-resistant MAC. 191 In addition, specialized references should be consulted for guidance on the use of rifamycins in HIV-infected patients receiving antiretroviral agents. 191 See Specific Drugs and Tests under Interactions. Ferreira, S. R. Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus. Nutr. caverta specialty pharmacy



Prescribing information for rifampicin

Inglesby TV, O'Toole T, Henderson DA et al for the Working Group on Civilian Biodefense. Anthrax as a biological weapon, 2002. Updated recommendations for management. JAMA. Agouron. Rescriptor delavirdine mesylate tablets prescribing information. Schwarz KB, Goldstein PD, Witztum JL, et al. Fat-soluble vitamin concentrations in hypercholestrolemic children treated with colestipol. If organism is susceptible to isoniazid and rifampin, pyrazinamide is continued for the first 2 months of a 6-month course of therapy 9-months if HIV positive. If primary drug resistance is shown, drug regimens should be adjusted as needed and continued for at least 6 months, or 3 months beyond culture conversion 9 months, or 6 months beyond culture conversion if HIV positive. If multiple-drug resistance is demonstrated, therapy should be continued for 12 to 24 months following culture conversion. Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin serine protease enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin, and thrombin-induced platelet aggregation are inhibited by the active moieties. If nausea of vomiting becomes a problem, rifabutin 150 mg orally every 12 hours is an alternative regimen. DALIRESP in pediatric patients have not been established. Wallach J. Interpretation of diagnostic tests. 4th ed. Boston: Little Brown and Company; 1986. p. 661. Oral rifampin should be given on an empty stomach 1 hour before or 2 hours after a meal with a full glass of water. Once-daily administration of oral rifampin is recommended for the treatment of tuberculosis. Henderson-Smart, D. J. Vitamin K prior to preterm birth for preventing neonatal periventricular haemorrhage. Cochrane. CYP 1A2 and 3A4. If your brand of multivitamin also contains iron, avoid taking this product at the same time as antacids, bisphosphonates for example, levodopa, for example, or some for example, tetracyclines, quinolones such as . Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications. Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening, with an onset of up to two months following cessation of therapy. Antibiotic therapy can alter the normal flora of the colon and permit overgrowth of Clostridium difficile, whose toxin is believed to be a primary cause of antibiotic- associated colitis. The colitis is usually characterized by severe, persistent diarrhea and severe abdominal cramps, and may be associated with the passage of blood and mucus. The most common culprits are clindamycin, lincomycin, the aminopenicillins amoxicillin, ampicillin and the cephalosporins. Therapy with broad-spectrum antibiotics and other agents with significant antibacterial activity should be administered cautiously in patients with a history of gastrointestinal diseases, particularly colitis. There is some evidence that pseudomembranous colitis, if it occurs, may run a more severe course in these patients and that it may be associated with flares in their underlying disease activity. The offending antibiotics should be discontinued if significant diarrhea occurs during therapy. Stool cultures for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically. A large bowel endoscopy may be considered to establish a definitive diagnosis in cases of severe diarrhea. CYP 2B6 by roflumilast. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rifampin, the following should be considered- Allergies--Tell your doctor if you have ever had any unusual or allergic reaction to rifampin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy--Pregnant women with tuberculosis TB should be treated with TB medicines, including rifampin. Rifampin can rarely cause bleeding in newborn babies and mothers when taken during the last weeks of pregnancy. Studies in rats and mice have shown that rifampin given in high doses causes birth defects, usually backbone problems spina bifida and cleft palate. Breast-feeding--Rifampin passes into the breast milk. However, rifampin has not been reported to cause problems in nursing babies. Children--This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems in children than it does in adults. Older adults--Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults.



What other drugs will affect rifampicin

Pyrazinamide is well absorbed from the gastrointestinal tract. It is not known if Pradaxa will harm your unborn baby. N-oxide metabolite are approximately 17 and 30 hours, respectively. Dabigatran is primarily eliminated by the kidneys with a low plasma protein binding of approximately 35%. Hemodialysis can remove dabigatran; however, data supporting this approach are limited. Chow, C. K. Dietary intake of menaquinones and risk of cancer incidence and mortality. prinivil



Indications and usage of rifampicin

Rifampin can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. LLC is recommended in the initial phase of short-course therapy which is usually continued for 2 months. The Advisory Council for the Elimination of Tuberculosis, the American Thoracic Society, and Centers for Disease Control and Prevention recommend that either streptomycin or ethambutol be added as a fourth drug in a regimen containing isoniazid INH rifampin, and pyrazinamide for initial treatment of tuberculosis unless the likelihood of INH resistance is very low. The need for a fourth drug should be reassessed when the results of susceptibility testing are known. If community rates of INH resistance are currently less than 4%, an initial treatment regimen with less than four drugs may be considered. Absorption of rifampin is reduced by about 30% when the drug is ingested with food. This is best taken on an empty with a full glass of water 8 ounces or 240 milliliters 1 hour before or 2 hours after meals; or take as directed by your doctor. Muthukumar T, Jayakumar M, Fernando EM, Muthusethupathi MA "Acute renal failure due to rifampicin: a study of 25 patients. Rifampin administration during the last few weeks of pregnancy can cause postnatal hemorrhages in the mother and infant; treat such hemorrhages with vitamin K. 161 Some experts recommend prophylactic administration of vitamin K 10 mg to neonates born to women who received rifampin during pregnancy. Eszopiclone is weakly bound to plasma protein 52-59%. Vandevelde C. Rifampin and ansamycin interactions with cyclosporine after renal transplantation. Pharmacotherapy 1991; 111: 88-9. The beneficial effects of your nifedipine may decrease. Murphy R, Swartz R, Watkins PB. Severe acetaminophen toxicity in a patient receiving isoniazid. Ann Intern Med 1990; 11310: 799-800. For initial treatment of active TB caused by drug-susceptible M. tuberculosis, recommended multiple-drug regimens consist of an initial intensive phase 2 months and a continuation phase 4 or 7 months.



Rifampicin drug interactions

The United States pharmacopeia. The national formulary. USP 24th revision January 1, 2000. NF 19th ed. January 1, 2000. Rockville, MD: The United States Pharmacopeial Convention Inc; 1999. p. 689-90. Co, Inc. Cancidas caspofungin acetate for injection prescribing information. Whitehouse Station, NJ; 2005 Feb. If any of these effects persist or worsen, tell your doctor or promptly. Leukopenia, hemolytic anemia, and decreased hemoglobin have been observed. Summaries for patients. Is vitamin K helpful for people who have taken too much warfarin? SM or ETB 3 times a week for 6 months. Treatment duration in these trials was 14 days. buy alendronate for cheap



Consult your doctor before -feeding

Sconce E, Avery P, Wynne H, Kamali F. Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin. No Grade 4 adverse reactions were reported. Rifampin has bactericidal activity in vitro against slow and intermittently growing M tuberculosis organisms. Staum JM. Enzyme induction: rifampin-disopyramide interaction. Ann Pharmacother 1990; 24: 701-3. Graaf, Y. Vitamin K intake and calcifications in breast arteries. DVT in both legs or any of the following: positive venography in one or both legs, or confirmed symptomatic DVT, PE, or death during the treatment period. IV for 4 to 6 months What other drugs will affect rifampin?



How should i store rifampicin

Minematsu, K. Optimal dose of prothrombin complex concentrate for acute reversal of oral anticoagulation. Thromb. See “What are the possible side effects of Pradaxa? Do not start, stop, or change the dosage of any medicine before checking with them first. Castel JM. Rifampicin lowers plasma concentrations of propafenone and its antiarrhythmic effect. Br J Clin Pharmacol 1990; 30: 155-6. When rifampin is taken during the last few weeks of pregnancy, the risk of bleeding in both mother and may be increased. Pyrazinamide is contraindicated in patients with severe hepatic disease and with acute gout. Psychiatric side effects have rarely included psychoses. LLC for at least 4 months. Treatment should be continued for longer if the patient is still sputum or culture positive, if resistant organisms are present, or if the patient is HIV positive. Rallis E, Koumantaki-Mathioudaki E. Treatment of Mycobacterium marinum cutaneous infections. Exp Opin Pharmacother. cheapest differin buy online canada



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Elevations in and serum have been reported


There may be new information

AHFS drug information 2007. McEvoy GK. Rifampin. In the four pivotal studies, patients on Pradaxa 150 mg had a similar incidence of gastrointestinal adverse reactions 24. Adalat nifedipine US prescribing information. Thijssen, H. H. and Drittij-Reijnders, M. J. Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4. chloramphenicol

How to use rifampicin

Your doctor or may already be aware of any possible and may be monitoring you for them. not start, stop, or change the dosage of any medicine before checking with them first. This medication may rarely cause a severe intestinal condition -associated due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Severe and sometimes fatal hepatitis associated with isoniazid therapy may occur and may develop even after many months of treatment. Kiely, M. Phylloquinone vitamin K1 intakes and serum undercarboxylated osteocalcin levels in Irish postmenopausal women.

What should i avoid while taking rifampicin

Amend W Jr. Enhancement of prednisolone elimination by anticonvulsants in renal transplant recipients. After absorption, rifampin is rapidly eliminated in the bile, and an enterohepatic circulation ensues. During this process, rifampin undergoes progressive deacetylation so that nearly all the drug in the bile is in this form in about 6 hours. This metabolite has antibacterial activity. Intestinal reabsorption is reduced by deacetylation, and elimination is facilitated. Up to 30% of a dose is excreted in the urine, with about half of this being unchanged drug. Edema of the face and extremities have been reported. Other reactions which have occurred with intermittent dosage regimens include “flu syndrome” such as episodes of fever, chills, headache, dizziness, and bone pain shortness of breath, wheezing, decrease in blood pressure and shock. The “flu syndrome” may also appear if rifampin is taken irregularly by the patient or if daily administration is resumed after a drug free interval.

Rifampicin adult dosage

Ltd. Eisai announces the intermediate analysis of anti-osteoporosis treatment post-marketing research to investigate the benefits of menatetrenone as part of the Ministry of Health, Labour and Welfare's Pharmacoepidemiological Drug Review Program. Due to the risk of optic neuritis associated with ethambutol, caution should be used when treating patients with preexisting neuritis or other vision defects. Ethambutol may produce decreases in visual acuity that appear to be due to optic neuritis. This effect may be related to dosage and duration of treatment. This effect is generally reversible when use of the drug is discontinued promptly. However, irreversible blindness has been observed. Since this drug may have adverse effects on vision, physical examination should include ophthalmoscopy, finger perimetry and testing of color discrimination. In patients with visual defects such as cataracts, recurrent inflammatory conditions of the eye, optic neuritis, and diabetic retinopathy, the evaluation of changes in visual acuity is more difficult, and care should be taken to make sure that variations in vision are not due to the underlying disease conditions. In these patients, consideration should be given to relationship between benefits expected and possible visual deterioration since evaluation of visual changes is difficult. All patients receiving ethambutol should be instructed to report any vision changes or disturbances. Testing of visual acuity should be performed before beginning ethambutol and periodically during drug administration. Monthly visual acuity testing should be done for patients receiving more than 15 mg per kilogram per day.

O'Brien RJ, Long MW, Cross FS, et al "Hepatotoxicity from isoniazid and rifampin among children treated for tuberculosis. Horowitz HW, Hsieh TC, Aquero-Rosenfeld ME et al. Antimicrobial susceptibility of Ehrlichia phagocytophila. Antimicrob Agents Chemother. Bredemann JA, Krechel SW, Eggers GWN. Treatment of refractory seizures in massive isoniazid overdose. It is freely soluble in methanol, slightly soluble in ethanol, and sparingly soluble in isopropanol. Drug Intell Clin Pharm.

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